public partial class Form1 : Form,IMessageFilter  
  {  
      public Form1()  
      {  
          InitializeComponent();  
      }  

      #region IMessageFilter 成员  
  
      public bool PreFilterMessage(ref Message m)  
      {  
          if (m.Msg == 522)  
          {  
              return true;  
          }  
          else  
          {  
              return false;  
          }  
      }  

      #endregion  
  
      private void Form1_Load(object sender, EventArgs e)  
      {  
          Application.AddMessageFilter(this );  
      }  
  }  

  private void Form1_Load(object sender, EventArgs e)
        {
            numericUpDown1.MouseWheel += new MouseEventHandler(numericUpDown1_MouseWheel);
        }

        //取消滚轮事件
        void numericUpDown1_MouseWheel(object sender, MouseEventArgs e)
        {
            HandledMouseEventArgs h = e as HandledMouseEventArgs;
            if (h != null)
            {
                h.Handled = true;
            }
        }