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INTRODUCTION TO BIOINFORMATICS
INTRODUCTION TO BIOINFORMATICS
这套教程源自Youtube,算得上比较完整的生物信息学领域的视频教程,授课内容完整清晰,专题化的讲座形式,细节讲解比国内的京师大学堂的Mooc教程好过10000倍.下面是视频的快速链接还有文档讲义哦,很好的东东,链接分享给国内的朋友们.
=课程主页:http://ocw.metu.edu.tr/course/view.php?id=37,
Instructor: Tolga CAN
Added: 18 November 2009
Topic outline
General
INTRODUCTION TO BIOINFORMATICS
- Course OverviewPage
- National Center for Biotechnology Information, USA.URL
- Protein Data BankURL
Topic 1
Introduction to Bioinformatics- Lecture SlidesFile
- Week 1 - Lecture 1 [Video]File
Topic 2
Introduction to biology, biological databases, and high-throughput data sources. Overview of bioinformatics problems.
Pairwise sequence alignment algorithms: Dynamic programming- Lecture SlidesFile
- Assignment 1File
- Reading: Bioinformatics - An Introduction for Computer ScientistsFile
- Reading: Cells and GenomesFile
- Reading: How Cells Read the Genome: From DNA to ProteinFile
- Reading: The Nucleic Acid WorldFile
- Reading: Producing And Analzying Sequence AlignmentsFile
- Week 2 - Lecture 1 [Video]File
- Week 2 - Lecture 2 [Video]File
- Week 3 - Lecture 1 [Video]File
- Week 3 - Lecture 2 [Video]File
- Week 4 - Lecture 1 [Video]File
- Week 4 - Lecture 2 [Video]File
Topic 3
Statistical significance of alignments - Part I
Statistical significance of alignments - Part II- Lecture SlidesFile
- Reading: Pairwise Sequence AlignmentFile
- Week 5 - Lecture 1 [Video]File
- Week 5 - Lecture 2 [Video]File
- Week 5 - Lecture 3 [Video]File
Topic 4
Suffix Trees, Suffix Arrays- Lecture SlidesFile
- Week 6 - Lecture 1 [Video]File
- Week 6 - Lecture 2 [Video]File
Topic 5
Patterns, Profiles, and Multiple Alignments- Lecture SlidesFile
- Assignment 2File
- Week 6 - Lecture 3 [Video]File
Topic 6
Hidden Markov Models
Week 5 Lecture Slides Continued- Week 7 - Lecture 1 [Video]File
- Week 7 - Lecture 2 [Video]File
- Week 7 - Lecture 3 [Video]File
Topic 7
Multiple Sequence Alignment Algorithms
Week 5 Lecture Slides Continued- Week 8 - Lecture 1 [Video]File
- Week 8 - Lecture 2 [Video]File
- Week 8 - Lecture 3 [Video]File
Topic 8
Midterm Review and Midterm Exam
- Midterm ExamFile
- Midterm KeyFile
Phylogenetic trees- Lecture SlidesFile
Topic 9
Introduction to protein structures
Structure Prediction- Lecture SlidesFile
- Assignment 3 for Computer Engineering MajorsFile
- Assignment 3 for Biology or Genetics MajorsFile
- Week 9 - Lecture 1 [Video]File
- Week 9 - Lecture 2 [Video]File
- Week 9 - Lecture 3 [Video]File
- Week 9 - Lecture 4 [Video]File
Topic 10
Protein Structure Prediction (continued)- Week 10 - Lecture 1 [Video]File
- Week 10 - Lecture 2 [Video]File
- Week 10 - Lecture 3 [Video]File
Topic 11
Protein Structure Prediction (continued)- Week 11 - Lecture 1 [Video]File
- Week 11 - Lecture 2 [Video]File
- Week 11 - Lecture 3 [Video]File
Topic 12
Structural Alignment of Proteins
(lecture notes continued)- Week 12 - Lecture 1 [Video]File
- Week 12 - Lecture 2 [Video]File
- Week 12 - Lecture 3 [Video]File
Topic 13
Microarray data normalization, analysis
Clustering techniques- Lecture SlidesFile
- K-means DemoFile
- Self Organizing Maps DemoFile
- Reading: Microarrays Intro Paper - 1File
- Reading: Microarrays Intro Paper - 2File
- Reading: Microarrays Intro Paper - 3File
- Week 13 - Lecture 1 [Video]File
- Week 13 - Lecture 2 [Video]File
Topic 14
Introduction to Systems Biology
Gene regulatory networks- Lecture SlidesFile
- Assignment 4File
- Dataset for Assignment 4File
- Week 14 - Lecture 1 [Video]File
Topic 15
Construction and Analysis of protein networks:
Monte Carlo Sampling, Random Walks on Graphs- Lecture SlidesFile
- Likelihood Computation ExampleFile
- Week 15 - Lecture 1 [Video]File
- Week 15 - Lecture 2 [Video]File
Final review
INTRODUCTION TO BIOINFORMATICS
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