from：http://jj.isgeek.net/2011/09/install-pil-with-jpeg-support-on-ubuntu-oneiric-64bits/

I am posting this because it took me ages to figure out how to solve this one.

I could not get PIL to compile with JPEG, Zlib or freetype support on my virtualenv. I am using Ubuntu Oneiric Beta1 on a Lenovo Thinkpad X220. That is a 64bit installation.

As read in every blog post out there, you first need to install the system libraries so PIL can find them.

$ sudo apt-get install libjpeg libjpeg-dev libfreetype6 libfreetype6-dev zlib1g-dev

After that, your regular pip install PIL should work under most situations. In my case I was still seeing this summary after the installation:

    ---------------------------------------------------------------    *** TKINTER support not available    --- JPEG support not available    --- ZLIB (PNG/ZIP) support not available    --- FREETYPE2 support not available    *** LITTLECMS support not available    ---------------------------------------------------------------

After a lot of googling around, I found this solution on Ubuntu forums.
It turns out that the APT installations put the libraries under /usr/lib/x86_64-Linux-gnu and PIL will search for them in /usr/lib/. So you have to create symlinks for PIL to see them.

# ln -s /usr/lib/x86_64-linux-gnu/libjpeg.so /usr/lib# ln -s /usr/lib/x86_64-linux-gnu/libfreetype.so /usr/lib# ln -s /usr/lib/x86_64-linux-gnu/libz.so /usr/lib

Now proceed and reinstal PiL, pip install -U PIL:

    ---------------------------------------------------------------    *** TKINTER support not available    --- JPEG support available    --- ZLIB (PNG/ZIP) support available    --- FREETYPE2 support available    *** LITTLECMS support not available    ---------------------------------------------------------------

tada  !

Update:
I just had this issue again on Ubuntu Precise, I found a solution here:
http://www.sandersnewmedia.com/why/2012/04/16/installing-pil-virtualenv-ubuntu-1204-precise-pangolin/

# ln -s /usr/lib/`uname -i`-linux-gnu/libfreetype.so /usr/lib/# ln -s /usr/lib/`uname -i`-linux-gnu/libjpeg.so /usr/lib/# ln -s /usr/lib/`uname -i`-linux-gnu/libz.so /usr/lib/

Note the uname -i that prints the box’s arquitecture. This is a much more generic solution!

How to do it on Ubuntu Precise Pagolin 12.04

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后来根据http://effbot.org/downloads/#Imaging PIL源码安装包中的README方法解决更方便：

sudo apt-get install libjpeg62-dev  sudo apt-get install zlib1g-dev  sudo apt-get install libfreetype6-dev  sudo apt-get install liblcms1-dev   

Install PIL with Jpeg support on Ubuntu Oneiric 64bit