Finding the words from the book that are not in the word list from words.txt is a problem you might recognize as set subtraction; that is, we want to find all the words from one set (the words in the book) that are not in another set (the words in the list).

subtract takes dictionaries d1 and d2 and returns a new dictionary that contains all the keys from d1 that are not in d2. Since we don’t really care about the values, we set them all to None.

……

Some of these words are names and possessives. Others are no longer in common use. But a few are common words that should really be on the list!

from Thinking in Python