using DevExpress.XtraGrid;
// ...
string fileName ="c:\\XtraGrid_SaveLayoutToXML.xml";

privatevoid Form1_Load(object sender, System.EventArgs e) {
   gridControl1.ForceInitialize();
   // Restore the previously saved layout
   gridControl1.MainView.RestoreLayoutFromXml(fileName);
}

privatevoid Form1_Closing(object sender, System.ComponentModel.CancelEventArgs e) {
   // Save the layout to an XML file
   gridControl1.MainView.SaveLayoutToXml(fileName);
}